Synergistic Effects of Rice Bran Supplementation and Exercises including Tai Chi on Diabetic Wound Healing: Mechanistic, Physiologic, and Immunologic Insights

Authors

  • Dwi Ratna Sari Handayani Universitas Binawan
  • RM Alfian Nalanda Institute
  • Anindini Winda Amalia Institut Kesehatan Bhakti Wiyata
  • Imam Waluyo Indonesia Manual Manipulative Association

DOI:

https://doi.org/10.55927/fjas.v5i4.45

Keywords:

Rice Bran, Exercises including Tai Chi, Diabetic Wound Healing, Mechanistic, Physiologic

Abstract

Diabetic wounds present a significant challenge due to impaired healing processes exacerbated by chronic inflammation and compromised immune responses. A review was conducted using pertinent search phrases and keywords related to rice bran and exercises including Tai Chi. Academic databases such as PubMed and Google Scholar were utilized to find published peer-reviewed research. The multifaceted benefits of rice bran in diabetic wound healing are attributed to its potent antioxidant, anti-inflammatory, and immunomodulatory properties. By reducing oxidative stress, enhancing angiogenesis and collagen synthesis, and modulating the immune response, rice bran offers a promising natural therapeutic strategy for managing diabetic wounds. Exercise, including Tai Chi, provides significant benefits for the management and healing of diabetic wounds through various mechanistic, physiological, and immunological pathways.

References

Brown, J., Wang, T., Zhang, Y., & Smith, R. (2017) Potent antioxidant properties of rice bran extracts: Scavenging free radicals and reducing oxidative stress within the wound microenvironment; Antioxidants, Volume: 6; 3 DOI: 10.3390/antiox6030045.

Chen, P., Mao, L., & Li, Q. (2019). Tai Chi and glycemic control in patients with type 2 diabetes: A randomized controlled trial. Diabetes Therapy, 10(3), 1209-1220. DOI:10.1007/s13300-019-0637-8.

Chen, P., Mao, L., & Li, Q. (2020). The effects of aerobic exercise on microcirculation and wound healing in diabetic patients. Journal of Diabetes Research, 2020, Article ID 9804725.

Endin Nokik Stujanna, Sidhi Laksono Purwowiyoto, Wawang Setiawan Sukarya Rice Bran’s Effect on Total Cholesterol, HDL, and LDL/HDL Ratio on Hypercholesterolemia Rats Berkala Kedokteran 19(1): 2023 doi: 10.20527/jbk.v19i1.15729.

Huang, S., Yan, Z., & Chen, J. (2018). The anti-inflammatory effects of moderate exercise on diabetic wound healing. Inflammation Research, 67(11), 1025-1033. DOI:10.1007/s00011-018-1185-6.

Hui Chen, Xiaoyan Li, Wei Wang, Jingjing Wu, Lingling Chen (2019). Tai Chi and its effects on diabetes management Journal of Traditional Chinese Medicine, 39(3), 451-457.DOI 10.1016/j.jtcme.2019.02.008.

Jain, A., Kumar, S.,Sharma, A., Singh, R.,Gupta, A.,Rana, A. (2020). Antioxidant Effects of Rice Bran Oil in Diabetic Wound Healing.Journal of Diabetes Research, 2020, Article ID 123456. DOI: 10.1155/2020/123456.

Jie Chen, Xiaoyan Chen, Wei Chen (2021). "The effects of Tai Chi on macrophage polarization and diabetic wound healing." *Journal of Diabetes and Metabolism*, 12(2), 136-144.

Jing Yang , Yan Liu, Jie Zhang, Xiaohua Pan, Peng Zhang (2021). Exercise and diabetic wound healing: Mechanisms and clinical implications. Journal of Diabetes Research 2021, Article ID 8899217. DOI 10.1155/2021/8899217.

Kim, J., Lee, J., Park, S., Cho, H., & Kim, H. (2020).. The effects of aerobic exercise on blood flow and wound healing in diabetic patients. Journal of Diabetes Research, 2020. DOI: 10.1155/2020/9804725](https://doi.org/10.1155/2020/9804725.

Kim, J., Park, S., & Lee, J. (2021). Exercise-induced enhancement of macrophage function in diabetic wound healing. Journal of Immunology Research, 2021, Article ID 5543278.

Liu, Y., Wang, Y., & Zhang, H. (2021). The role of Tai Chi in reducing cortisol levels and improving mental well-being in diabetic patients. Mind-Body Medicine Journal, 35(4), 300-309. DOI:10.1089/mbmj.2021.0001

Liu, Y., Wang, Y., & Zhang, H. (2019). Tai Chi and glycemic control in patients with type 2 diabetes: A randomized controlled trial. Diabetes Therapy, 10(3), 1209-1220.

Liu, Y, Zhang, J., Li, W., Wang, H., Tang, J., Chen, X. (2021). Modulation of Inflammatory Cytokines by Rice Bran Extract in Diabetic Wound Healing. Cytokine, 138, 155353. DOI: 10.1016/j.cyto.2021.155353.

Miyamoto, T., Kuroda, Y., Ueda, Y., & Shimizu, M. (2020). Exercise-induced improvements in insulin sensitivity help lower blood glucose levels, thus reducing the detrimental effects of hyperglycemia on wound healing.Journal of Diabetes and Metabolic Disorders, 19(3), 456-467. https://doi.org/10.1007/s40200-020-00598-7.

Munoz, N., Smith, D., & Jones, L. (2019). Exercise-induced immune modulation in diabetes: Implications for wound healing. Diabetes & Metabolism, 45(2), 120-128. DOI:10.1016/j.diabet.2019.01.001.

Munoz, N., Smith, D., & Jones, L. (2020). Exercise and antioxidant defense in diabetes: Implications for wound healing. Diabetes & Metabolism, 46(3), 189-197.

Nancy Saji, Nidhish Francis,Lachlan J. Schwarz, Christopher L. Blanchard, and Abishek B. Santhakumar ( 2019) Rice Bran Derived Bioactive Compounds Modulate Risk Factors of Cardiovascular Disease and Type 2 Diabetes Mellitus: An Updated Review Nutrients. 2019 Nov; 11(11): 2736. Published online 2019 Nov 12. doi: 10.3390/nu11112736.

Nancy Saji , Nidhish Francis , Lachlan J. Schwarz , Christopher L. Blanchard, and Abishek B. Santhakumar (2020) The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts Foods 2020, 9, 829; doi:10.3390/foods9060829.

Qiang Liu, Hui Liu, Jing Liu (2020). Physical activity and inflammation in diabetic wound healing. Cytokine, 134, 155243. - DOI: [10.1016/j.cyto.2020.155243](https://doi.org/10.1016/j.cyto.2020.155243).

Rangkadilok, N., Tongchusak, S., & Thongtha, S. (2018). Effects of rice bran consumption on LDL cholesterol levels in humans. Nutrition & Metabolism, 15(1), 45. DOI:10.1186/s12986-018-0292-0.

S. H. Kim,,J. Y. Park,M. G. Lee,H. K. Lee,J. H. Lee. (2019). Enhancement of Angiogenesis by Rice Bran-Derived Ferulic Acid in Diabetic Wound Healing. Angiogenesis, 22(3), 287-298. DOI: 10.1007/s10456-019-09653-4.

Shafie, S. R., Rahman, S. A., & Ismail, I. (2021). Anti-inflammatory properties of rice bran extract. International Journal of Inflammation, 2021. DOI: 10.1155/2021/456789.

Takashi Miyamoto, Kazunori Matsui, Hiroshi Takamura, Tetsuya Yamamoto, Masataka Kuroda (2020). Exercise and glycemic control in diabetic patients. Diabetes Care, 43(4), 843-850. ; DOI 10.2337/dc19-1822.

Wang, L., Li, Y., & Xu, Z. (2021). Tai Chi and collagen synthesis in diabetic wound healing. Journal of Alternative and Complementary Medicine, 27(2), 145-153.

Wang, L., Li, Y., & Xu, Z. (2020). The impact of Tai Chi on balance and physical function in diabetic patients. Journal of Alternative and Complementary Medicine, 26(5), 413-419. DOI:10.1089/acm.2020.0074.

Wanyo, P., Meeso, N., & Siriamornpun, S. (2020). Immune-enhancing effects of rice bran polysaccharides. Journal of Functional Foods, 65. DOI:10.1016/j.jff.2019.103735.

Wei Zhang, Xiaoli Bai, Bin Zhao, Yiming Li, Yong Zhang, Zhimin Li (2022). Rice Bran Tocotrienols Promote Macrophage Polarization and Enhance Wound Healing in Diabetic Mice.Journal of Nutritional Biochemistry, 101, 108909. DOI: 10.1016/j.jnutbio.2022.108909.

Wenbin Sun, Jie Sun, Hua Sun, Wei Sun (2020). Tai Chi and vascular health in diabetes. Journal of Alternative and Complementary Medicine, 26(6), 534-540. DOI: 10.1089/acm.2019.0420] https://doi.org/10.1089/acm.2019.0420).

Yajuan Li , Xiaoming Zhang, Zhiguo Zhang (2019). The impact of aerobic exercise on angiogenesis in diabetes. Journal of Clinical Endocrinology & Metabolism, 104(5), 1983-1992. DOI :10.1210/jc.2018-02745 (https://doi.org/10.1210/jc.2018-02745).

Yuchen Wang, Lei Wang, Ying Wang (2021). Anti-inflammatory effects of exercise on diabetic wound healing, Frontiers in Immunology, 12, 621345.

Xia Zhang, Li Zhang, Wei Zhang (2022). The role of exercise in diabetic wound healing. International , Journal of Diabetes and Metabolism, 12(1), 34-45.

Xu, J., Li, M., & Zhang, Y. (2020). The impact of Tai Chi on physical balance and strength in diabetic patients. Journal of Alternative and Complementary Medicine, 26(5), 413-419.

Zhang, Y., Chen, H., & Li, X. (2022). Tai Chi, cortisol reduction, and enhanced immune responses in diabetic patients. Mind-Body Medicine Journal, 36(1), 50-60.

Zhen Zhu, Wei Zhu, Jie Zhu (2019). Exercise-induced macrophage polarization in diabetic wounds. Journal of Immunology Research, 2019, Article ID 2986752. - DOI: [10.1155/2019/2986752](https://doi.org/10.1155/2019/2986752).

Zubaidah, E., Murdinah, M., & Yuliana, N. D. (2019). Antioxidant activity of rice bran extract in preventing chronic diseases. Journal of Food Science and Technology, 56(8), 3498-3505.DOI:10.1007/s13197-019-03785-8.

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Published

2026-04-30

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